Drug List
We currently offers DNA Prescription Drug Reaction Profiles that test 2D6,2C9, and 2c19 functionality. The table below lists many commonly prescribed drugs that are metabolized through these pathways in the Cytochrome P-450 system. If your medication is not on the list, ask your pharmacist or physician about the metabolic pathway.
We expect our clients to seek professional advice concerning any medical or legal actions that might be suggested by the information we offer. Do not alter the dosage amount or schedule of any drug you are taking without first consulting your doctor or pharmacists.
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| Anti-Coagulation | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
|---|---|---|
| WARFARIN | COUMADIN | CYP2C9* and VKORC1* |
| Tricyclic Anti-Depressants | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| AMITRIPTYLINE | VARIOUS BRAND NAMES | CYP2D6 |
| CLOMIPRAMINE | ANAFRANIL | CYP2D6 |
| DESIPRAMINE | NORPRAMIN | CYP2D6 |
| DOXEPIN | SINEQUAN | CYP2D6* |
| IMIPRAMINE | TOFRANIL | CYP2D6 |
| NORTRIPTYLINE | PAMELOR | CYP2D6 |
| NORTRIPTYLINE | AVENTYL | CYP2D6 |
| Anti-Psychotics and SSRI's | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| ARIPIPRAZOLE | ABILIFY | CYP2D6* |
| FLUOXETINE | PROZAC | CYP2D6* |
| FLUOXETINE | SARAFEM | CYP2D6* |
| Maprotoline | Ludiomil | CYP2D6 |
| PAROXETINE | PAXIL | CYP2D6 |
| RISPERIDONE | RISPERDAL | CYP2D6* |
| Beta Blockers | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| Carvedilol | Coreg | CYP2D6 |
| METOPROLOL | TOPROL-XL | CYP2D6* |
| METOPROLOL | LOPRESSOR | CYP2D6* |
| PROPANOL0L | VARIOUS BRAND NAMES | CYP2D6 |
| Anti-Hyperglycemics | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| GLIMEPIRIDE | AMARYL | CYP2C9 |
| GLIPIZIDE | GLUCOTROL | CYP2C9 |
| GLYBURIDE | DIABETA | CYP2C9 |
| Proton Pump Inhibitors | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| LANSOPRAZOLE | PREVACID | CYP2C19 |
| OMEPRAZOLE | PRILOSEC | CYP2C19* |
| PANTOPROZOLE | PROTONIX | CYP2C19 |
| RABEPRAZOLE | ACIPHEX | CYP2C19 |
| NSAID's | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| CELECOXIB | CELEBREX | CYP2C9* |
| Ibuprofen | Advil | CYP2C9 |
| Ibuprofen | Motrin | CYP2C9 |
| Naproxen | Aleve | CYP2C9 |
| Oploids | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| Codeine | Codeine Phosphate | CYP2D6 |
| Dextromethorphan | Various Brand Names | CYP2D6 |
| Anti-Epileptics | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| PHENYTOIN | DILANTIN | CYP2C9 |
| SNRI's | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| ATOMOXETINE | STRATTERA | CYP2D6* |
| VENLAFAXINE | EFFEXOR | CYP2D6* |
| OTHER DRUGs TO NOTE | ||
| Generic Name | Brand Name | Metabolizing Enzyme |
| DIAZEPAM | VALIUM | CYP2C19 |
| Donepezil | Aricept | CYP2D6 |
| Flecanide | Tambocor | CYP2D6 |
| Fluvastatin | Lescol | CYP2C9 |
| Hydrocodone | Various Brand Names | CYP2D6 |
| Loratadine | Claritin | CYP2D6 |
| Losartan | Cozaar | CYP2C9 |
| Oxycodone | Oxycontin | CYP2D6 |
| PROPANFENONE | RYTHMOL | CYP2D6* |
| Tamoxifen | Various Brand Names | CYP2D6 |
| THEOPHYLLINE | VARIOUS BRAND NAMES | CYP1A2 * |
| Tramadol | Ultram | CYP2D6 |
|
* Information regarding importance of genetic cariability contained in manufacturer's product labeling.
Lower case - potential for less severe complication sor potential complicatoins associated with drug-drug interaction. ALL CAPS w/ BOLD - indicates potential for significantly increased risk of adverse events. Important Message: Pharmacogenetic (PG) testing identifies patients who may have increased risk of side effects from drug accumulation (Poor and Intermediate Metabolizers, PM and IM) or lack of efficacy due to rapid drug elimination (Ultrarapid Metabolizers, UM). This knowledge can be used to minimize the chance of adverse reactions or therapeutic failure by guiding optimal selection and dosage of medicaions. Please contact the experts at PGXL for specific consultation. |
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