Solute Carrier Organic Anion Transporter 1B1 (SLCO1B1) Genotyping
Whole blood or buccal swabs
5 mL of whole blood or four buccal swabs
3 mL of whole blood or four buccal swabs
Lavender-stopper (EDTA) tube or paper envelope for dried buccal swabs
Maintain at room temperature or refrigerate
Cause for Rejection
Hemolyzed specimen; quantity not sufficient
General Purpose and Use
The SLCO1B1 gene encodes the liver enzyme OATP1B1, which assists in transport of statins medications into the liver. Roughly 15% of the population possess the *5 variant, an inherited form of SLOC1B1 which increases risk of statin-induced myopathy 3 to 5 fold. Risk of myopathy with the *5 variant is most closely associated with simvastatin and to a lesser extent, atorvastatin. Patients with the *5 variant may need the lowest doses of simvastatin or an alternative statin to reduce risk of myopathy.
Other variants of the SLCO1B1 gene that are not detected in this assay may influence drug response. All factors should be considered as part of the overall patient management strategy.
Real-time polymerase chain reaction with fluorescence detection.
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